Sr. Mechanical Engineer

Company Info
Xcell Biosciences
San Francisco, CA, United States

Phone: (415) 937-0321
Web Site:

Company Profile


Sr. Mechanical Engineer


San Francisco, CA 


110,000 - 150,000

Job ID:


Job Description:

Xcellbio is an venture-backed immuno-oncology focused technology startup based in San Francisco. Our rapidly growing company has had success in raising multiple financing rounds from some of the top venture capital names in the industry. Our mission is to enhance the performance and safety of cell and gene therapies through the design and development of a suite of innovative technology platforms. Our commercial instruments and AI-driven software enable researchers to discover novel insights into immune and tumor biology. Our product development team is working to translate these insights at patient-scale, through the development of a novel cell therapy manufacturing technology. We are focused specifically on the cell therapy processing unit function of cell maintenance and expansion to leverage our unique IP positioning and know-how to improve therapeutic potency and persistence during the manufacturing process. Our fun, well-capitalized, and mission-driven team is expanding several fold in the near-term – now is a great time to join and a great time to lead our technology driven organization!

Description of Position:

We are looking for a creative, engineering and process-minded individual with recent experience in product and/or process development within the biotech space to join our recent Series B-funded high growth startup as a Sr. Hardware Engineer. This individual will have a key role in supporting our cell therapy manufacturing technology development for an industry-leading manufacturing system for personalized/autologous cell therapies. You will have ownership of specific subsystem designs through beta prototype creation. An ideal candidate will have direct experience developing incubator/bioreactor instrumentation. In this role, you will engage in all facets of product development including concepting, documentation, design, prototyping and transfer to manufacturing. The candidate must have the drive to solve complex technical problems, work in a fast-paced environment, across multiple stakeholders and subject matter experts.


Key Responsibilities:

  • Collaborate with a diverse group of engineers, biologists, software designers, end-users and external suppliers
  • Participate in the translation of user and functional requirements to design specification, concepts and direction
  • Execute project scope including systems integration and design and development of a number of key subsystems, including sensor technologies, liquid handling systems, and cell washing
  • SolidWorks based design and development of instrumentation and consumables for cell therapy manufacturing
  • Generate and review documentation required for manufacturing technical transfers
  • Support of activities pertaining to market-readiness of product, including qualification activities


Education, Experience, and Skill Requirements:

  • Masters or Bachelor’s in Mechanical Engineering or related field with emphasis on CAD design and prototyping
  • 2-5 years of experience in a company that develops bioprocessing/cell manufacturing equipment **Candidates with more experience and/or domain expertise may be considered for Manager positions
  • Experience working with outside vendors to quickly develop prototypes and production instruments
  • Candidates with direct experience in immune cell therapy processing workflows will be given priority
  • Highly motivated self-starter who can prioritize and take ownership of tasks
  • Excited to be “hands-on” in solving product problems
  • Must be comfortable in a rapidly growing and evolving start-up environment
  • Please note if you are legally authorized to work in the United States in your application